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Il1rl2 interleukin 1 receptor-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171106, updated on 2-Nov-2024

Summary

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Official Symbol
Il1rl2provided by RGD
Official Full Name
interleukin 1 receptor-like 2provided by RGD
Primary source
RGD:621782
See related
EnsemblRapid:ENSRNOG00000014683 AllianceGenome:RGD:621782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of inflammatory response. Predicted to act upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 10.1), Lung (RPKM 9.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il1rl2 in Genome Data Viewer
Location:
9q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (50087271..50134225)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42591658..42639351)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (47044870..47093679)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene H3.3 histone A like 3 Neighboring gene interleukin 1 receptor type 1 Neighboring gene interleukin 1 receptor-like 1 Neighboring gene interleukin 18 receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Luo C, et al. Med Sci Monit, 2020 Feb 12. PMID 32048631, Free PMC Article
  2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). Lovenberg TW, et al. J Neuroimmunol, 1996 Nov. PMID 8898719
  3. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. Tortola L, et al. J Clin Invest, 2012 Nov. PMID 23064362, Free PMC Article
  4. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. Vigne S, et al. Blood, 2012 Oct 25. PMID 22968459
  5. IL-36R ligands are potent regulators of dendritic and T cells. Vigne S, et al. Blood, 2011 Nov 24. PMID 21860022

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
    Title: Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-like 2
Names
IL-1Rrp2
IL-36 receptor
IL1R-rp2
interleukin-1 receptor-related protein 2
NP_598259.2
XP_017451748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133575.2 → NP_598259.2  interleukin-1 receptor-like 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q62929
    UniProtKB/TrEMBL
    A6INN3, G3V7W4
    Related
    ENSRNOP00000110127.1, ENSRNOT00000135930.1
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:26 → 115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    50087271..50134225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596259.3 → XP_017451748.1  interleukin-1 receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q62929
    UniProtKB/TrEMBL
    A6INN3, G3V7W4
    Related
    ENSRNOP00000098736.1, ENSRNOT00000137233.1
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:26 → 115
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62929.1 GenPept UniProtKB/Swiss-Prot:Q62929

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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